Effective Determinant Factors on the Quality of Life in Hypertensive Wakatobi Patients, Indonesia. Health Educ Health Promot 2025; 13 (4) :617-623 URL: http://hehp.modares.ac.ir/article-4-82920-en.html
Aims:This study aimed to analyze the role of medication adherence as a mediator in the relationship between determinant factors and quality of life among hypertensive patients in the coastal communities of Wakatobi District. Instrument & Methods:This cross-sectional design with a quantitative approach was conducted on200 hypertensive patients living in the coastal areas of Wakatobi District selected using multistage cluster sampling. Data were collected through structured interviews using the WHO Quality of Life Assessment Instrument for quality of life, the Morisky Medication Adherence Scale for medication adherence, and questionnaires on social support, illness perception, knowledge, attitude, and motivation. Data analysis was done using Chi-square tests, and multivariate analysis using structural equation modeling-partial least squares with SmartPLS. Findings:Social support, illness perception, knowledge, attitude, and motivation were significantly associated with medication adherence (p<0.05). Medication adherence was also significantly associated with quality of life (p=0.013). SEM-PLS confirmed that adherence served as a mediator in the relationship between determinant factors and quality of life. Conclusion:Medication adherence plays a crucial mediating role in the relationship between determinant Factors and the quality of life of hypertensive patients in the coastal communities of Wakatobi District.