en <span style=font-size:11pt><span style=line-height:normal><span style=font-family:Calibri,sans-serif><a name=_Hlk209690061><b><span style=font-size:10.0pt><span style=font-family:Cambria,serif><span style=color:#4f81bd>Aims:</span></span></span></b></a> <span style=font-size:10.0pt><span style=font-family:Cambria,serif>This study aimed to analyze the role of medication adherence as a mediator in the relationship between determinant factors and quality of life among hypertensive patients in the coastal communities of Wakatobi District.</span></span></span></span></span><br> <span style=font-size:11pt><span style=line-height:normal><span style=font-family:Calibri,sans-serif><b><span style=font-size:10.0pt><span style=font-family:Cambria,serif><span style=color:#4f81bd>Instrument & Methods:</span></span></span></b> <span style=font-size:10.0pt><span style=font-family:Cambria,serif>This cross-sectional design with a quantitative approach was conducted on200 hypertensive patients living in the coastal areas of Wakatobi District selected using multistage cluster sampling. Data were collected through structured interviews using the WHO Quality of Life Assessment Instrument for quality of life, the </span></span><span style=font-size:10.0pt><span style=font-family:Cambria,serif>Morisky Medication Adherence Scale </span></span><span style=font-size:10.0pt><span style=font-family:Cambria,serif>for medication adherence, and questionnaires on social support, illness perception, knowledge, attitude, and motivation. Data analysis was done using Chi-square tests, and multivariate analysis using structural equation modeling-partial least squares with SmartPLS.</span></span></span></span></span><br> <span style=font-size:11pt><span style=line-height:normal><span style=font-family:Calibri,sans-serif><b><span style=font-size:10.0pt><span style=font-family:Cambria,serif><span style=color:#4f81bd>Findings:</span></span></span></b> <span style=font-size:10.0pt><span style=font-family:Cambria,serif>Social support, illness perception, knowledge, attitude, and motivation were significantly associated with medication adherence (p<0.05). Medication adherence was also significantly associated with quality of life (p=0.013). SEM-PLS confirmed that adherence served as a mediator in the relationship between determinant factors and quality of life. </span></span></span></span></span><br> <span style=font-size:11pt><span style=line-height:normal><span style=font-family:Calibri,sans-serif><b><span style=font-size:10.0pt><span style=font-family:Cambria,serif><span style=color:#4f81bd>Conclusion:</span></span></span></b> <span style=font-size:10.0pt><span style=font-family:Cambria,serif>Medication adherence plays a crucial mediating role in the relationship between determinant Factors and the quality of life of hypertensive patients in the coastal communities of Wakatobi District.</span></span></span></span></span><br> Hypertension, Medication Adherence, Quality of Life , Cross-Sectional Studies, Patients 617 623 http://hehp.modares.ac.ir/browse.php?a_code=A-10-73688-4&slc_lang=en&sid=4