Aims:This study aimed to investigate the perceived importance and effectiveness of various communication strategies for promoting blood donation and to examine their associations with demographic and behavioral factors. Instrument & Methods:This cross-sectional study using face-to-face and online survey was conducted on Moroccan adults aged 18-65 years. Data were cleaned (invalid rate 13.3%) and analyzed in Python, and visualized in Power BI. Associations were tested using Chi-square (χ²) tests and t-tests, with multivariable logistic regression adjusted for donation status, age, gender, marital status, education, and occupation status. Findings: A total of 664 valid questionnaires (366 donors and 298 non-donors) were included. Donors were significantly older (odds ratio=1.04 per year, p<0.001) and more educated (odds ratio=1.32 per level, p=0.001), while non-donors were younger and single. Regarding blood need and urgency, donors were more likely to have personally needed blood (odds ratio=1.28 per level, p=0.003). Gender and occupation were not independent predictors (p>0.05). In terms of promotion strategies, digital platforms, such as social media engagement (odds ratio=1.49, p=0.033) increased the odds of being a donor, whereas the use of mobile applications (odds ratio=0.55, p<0.001) and appointment/traceability systems (odds ratio=0.68, p=0.009) decreased those odds. Conclusion:Social media and in-person outreach improves donor recruitment and retention methods.