Aims: This research aimed to investigate the spread of COVID-19 infection among suspected adults and assess the relationship between tobacco smoking, diabetes, and high blood pressure comorbidities, and their association with susceptibility to acquiring the infection with COVID-19. Material & Methods: This study was carried put on 214 suspected cases of CoV-2, among male and female adults (age ≥ 20 years) in 2021, and tested for CoV-2 infection by RT-PCR. Plus the IgG/IgM Rapid Test Cassette, along with CoV-2-related symptoms. Information on whether the subjects smoke or suffer from diabetes and high blood pressure has also been supplemented. Findings: According to the results, the age group of 61-80 was the most affected group among the COVID-19 patients by 45%. In addition, the proportion of males infected with COVID-19 was higher across all age groups (64%) than females (36%). A significant difference was observed between the patients concerning age and gender (p<0.05). The percentage of smoker patients versus non-smokers was 47% vs 53%. The proportion of diabetics to nondiabetics was 43 % vs 57 %. As well as the ratio of hypertensive to normotensive COVID-19 patients was 62 % vs 38 %. There was a significant difference between smoker and non-smoker, diabetic and non-diabetic, and hypertensive and non-hypertensive patients in terms of affected by COVID-19 (p<0.05). Conclusion: Age, gender, smoking, diabetes, and hypertension are some risk factors for Coronavirus infection. Gender and age are associated with infection rates and their consequences. Also, the likelihood of COVID-19 infection is likely to be lowered in half for active smokers. Patients with diabetes and hypertension especially those who use ACE2-increasing medications are at a higher risk of developing a severe COVID-19 infection.