en <span style=font-size:10pt><span style=unicode-bidi:embed><span new= roman= style=font-family: times=><b><span cambria= style=font-family:><span style=color:black>Aims:</span></span></b><span cambria= style=font-family:><span style=color:black> This research aimed to investigate the spread of COVID-19 infection among suspected adults and assess the relationship between tobacco smoking, diabetes, and high blood pressure comorbidities, and their association with susceptibility to acquiring the infection with COVID-19.</span></span></span></span></span><br> <span style=font-size:10pt><span style=unicode-bidi:embed><span new= roman= style=font-family: times=><b><span cambria= style=font-family:><span style=color:black>Material & Methods:</span></span></b><span cambria= style=font-family:><span style=color:black> This study was carried put on 214 suspected cases of CoV-2, among male and female adults (age ≥ 20 years) in 2021, and tested for CoV-2 infection by RT-PCR. Plus the IgG/IgM Rapid Test Cassette, along with CoV-2-related symptoms. Information on whether the subjects smoke or suffer from diabetes and high blood pressure has also been supplemented.</span></span></span></span></span><br> <span style=font-size:10pt><span style=unicode-bidi:embed><span new= roman= style=font-family: times=><b><span cambria= style=font-family:><span style=color:black>Findings</span></span></b><b><span cambria= style=font-family:><span style=color:black>: </span></span></b><span cambria= style=font-family:><span style=color:black>According to the results, the age group of 61-80 was the most affected group among the COVID-19 patients by 45%. In addition, the proportion of males infected with COVID-19 was higher across all age groups (64%) than females (36%). A significant difference was observed between the patients concerning age and gender (p<0.05). The percentage of smoker patients versus non-smokers was 47% <i>vs</i> 53%. The proportion of diabetics to nondiabetics was 43 % <i>vs</i> 57 %. As well as the ratio of hypertensive to normotensive COVID-19 patients was 62 %<i> vs</i> 38 %. There was a significant difference between smoker and non-smoker, diabetic and non-diabetic, and hypertensive and non-hypertensive patients in terms of affected by COVID-19 (p<0.05). </span></span><b><span dir=RTL lang=AR-SA style=font-size:12.0pt><span iransharpsmall= light= style=font-family:><span style=color:black></span></span></span></b></span></span></span><br> <span style=font-size:10pt><span style=unicode-bidi:embed><span new= roman= style=font-family: times=><b><span cambria= style=font-family:><span style=color:black>Conclusion</span></span></b><span cambria= style=font-family:><span style=color:black>: Age, gender, smoking, diabetes, and hypertension are some risk factors for Coronavirus infection. Gender and age are associated with infection rates and their consequences. Also, the likelihood of COVID-19 infection is likely to be lowered in half for active smokers. Patients with diabetes and hypertension especially those who use ACE2-increasing medications are at a higher risk of developing a severe COVID-19 infection. </span></span></span></span></span><br> SARS-CoV-2, COVID-19, Diabetes Mellitus, Hypertension, Smoking 587 591 http://hehp.modares.ac.ir/browse.php?a_code=A-1-71775-1&slc_lang=en&sid=4