Aims: This study aimed to explore the perceptions of adolescent e-cigarette users and non-users toward various types of message appeals in e-cigarette prevention campaigns. Participants & Methods:This qualitative study employed the focus group discussion technique with 51 high school adolescents, including those who used e-cigarettes (vape group) and those who did not (non-vape group). Participants were selected by the school for this study. Data analysis was conducted using thematic analysis. Findings:Emotional appeals had a strong influence on both groups, particularly messages featuring testimonials from former users. Rational appeals were considered less appealing despite presenting important data; however, combining them with emotional appeals was regarded as more ideal. Although not all participants liked humorous appeals, both groups agreed that they enjoyed the humor appeal of Dr. Tirta, a doctor who has become an influencer on social media. Fear appeals were considered more effective for early adolescents who have never tried e-cigarettes, as they tend to be underestimated by those who have already experienced addiction. Customizing e-cigarette prevention messages based on adolescents’ experiences could enhance message effectiveness. Emotionally resonant messages that present facts with credible delivery offer a promising strategy for adolescent-focused public health campaigns. Conclusion:A combination of fact-based, emotionally resonant messages delivered by credible individuals is a promising alternative strategy for adolescent-focused public health campaigns.