Aims: This study investigated the dimensions of mental health literacy and its relationship with quality of life among students at Zahedan University of Medical Sciences. Instrument & Methods: This cross-sectional descriptive study utilized a stratified cluster sampling method involving 220 students in 2024. Data were collected using a Mental Health Literacy Scale and a Quality of Life Scale. Data were analyzed using SPSS 24 with independent sample t-tests, one-way ANOVA, and logistic regression analysis. Findings: The means and standard deviations of mental health literacy and quality of life were 83.96±7.62 and 33.98±6.22, respectively. There was a significant relationship between mental health literacy and the quality of life of students. There were significant correlations between mental health literacy and sex, education level, family history of mental illness, referral to a psychologist/psychiatrist, and place of residence (p<0.001). Additionally, there was a significant relationship between quality of life and sex, education level, and history of mental illness (p<0.001). Participants’ ability to recognize mental disorders, knowledge of available professional help, and attitudes toward help-seeking behavior were significantly associated with a family history of mental illness. Conclusion: There is a significant relationship between mental health literacy and quality of life among students at Zahedan University of Medical Sciences.