en <span style=font-size:11pt><span style=line-height:normal><span style=font-family:Aptos,sans-serif><b><span style=font-size:10.0pt><span style=font-family:Cambria,serif><span style=color:#4f81bd>Aims:</span></span></span></b> <span style=font-size:10.0pt><span style=font-family:Cambria,serif>This study examined the relationship between innovation practices and occupational fatigue among healthcare professionals in a high-intensity oncology setting.</span></span></span></span></span><br> <span style=font-size:11pt><span style=line-height:normal><span style=font-family:Aptos,sans-serif><b><span style=font-size:10.0pt><span style=font-family:Cambria,serif><span style=color:#4f81bd>Instrument & Methods:</span></span></span></b><span style=font-size:10.0pt><span style=font-family:Cambria,serif> This cross-sectional study was conducted at the Sultan Qaboos Comprehensive Cancer Center (SQCCC) in Muscat, Oman in 2024, involving 163 clinical staff members. Data were collected using validated self-reported questionnaires that measured innovation practices, occupational fatigue, and demographic characteristics. Descriptive statistics, correlation analyses, and independent samples t-test were performed to identify significant relationships and demographic differences.</span></span></span></span></span><br> <span style=font-size:11pt><span style=line-height:normal><span style=font-family:Aptos,sans-serif><b><span style=font-size:10.0pt><span style=font-family:Cambria,serif><span style=color:#4f81bd>Findings:</span></span></span></b> <span style=font-size:10.0pt><span style=font-family:Cambria,serif>Innovation practices were rated highly across domains, with resource allocation scoring the highest (4.26±0.42). Occupational fatigue levels were relatively low overall (1.73±1.03), with shift-related fatigue being the most prominent (1.92±0.85). A significant negative correlation was identified between occupational fatigue and innovation (r=-0.68, p<0.05). Leadership behaviors (r=-0.62, p<0.05) and organizational climate (r=-0.59, p<0.05) showed the strongest negative associations with fatigue. Participants aged over 40 reported higher fatigue levels compared to younger professionals aged 20-40. Additionally, professionals with over 10 years of experience exhibited significantly higher innovation scores (p=0.032) and lower fatigue levels (p=0.027) than their less experienced counterparts.</span></span></span></span></span><br> <b><span style=font-size:10.0pt><span style=line-height:107%><span style=font-family:Cambria,serif><span style=color:#4f81bd>Conclusion:</span></span></span></span></b> <span style=font-size:10.0pt><span style=line-height:107%><span style=font-family:Cambria,serif>Demographic factors, such as age, experience, and education, play significant roles in shaping perceptions of fatigue and innovation. </span></span></span> Organizational Innovation,Occupational Health,Fatigue,Leadership, 13 19 http://hehp.modares.ac.ir/browse.php?a_code=A-10-85562-2&slc_lang=en&sid=4