en <span style=line-height:normal><b><span style=font-size:10.0pt><span cambria= style=font-family:><span style=color:#4f81bd>Aims:</span></span></span></b><span style=font-size:10.0pt><span cambria= style=font-family:> There are approximately 422.7 million cases of acute coronary syndrome worldwide. This study assessed the effect of affective stimulation-based, family-centered integrated spiritual support on relieving chest pain and anxiety in patients with acute coronary syndrome in the coronary intensive care unit.</span></span></span><br> <span style=line-height:normal><b><span style=font-size:10.0pt><span cambria= style=font-family:><span style=color:#4f81bd>Materials & Methods:</span></span></span></b><span style=font-size:10.0pt><span cambria= style=font-family:> This pilot study employed a quasi-experimental pre- and post-test design with a non-equivalent control group. Thirty respondents were selected using consecutive sampling techniques and divided into the experimental (n=15) and control (n=15) groups. The experimental group received routine care along with the program, while the control group received only routine care. The Numeric Pain Rating Scale was used to measure chest pain, and the Visual Analog Scale for Anxiety was used to assess anxiety. Data analysis began with a normality test using the Shapiro-Wilk test, followed by a homogeneity test using Levene's and Chi-square tests. Univariate analysis was conducted using frequency, percentage, mean, and standard deviation, concluding with a paired t-test, an independent t-test, Cohen’s d, and analysis of covariance.</span></span></span><br> <span style=line-height:normal><b><span style=font-size:10.0pt><span cambria= style=font-family:><span style=color:#4f81bd>Findings:</span></span></span></b><span style=font-size:10.0pt><span cambria= style=font-family:> Most respondents were males diagnosed with non-ST-elevation myocardial infarction. There was a statistically significant difference in the mean pain and anxiety scores between the pre-test and post-test in each group. There was a significant difference between the experimental and control groups regarding the average patient anxiety score, with an effect size of 0.807, but no significant difference in the average patient pain score.</span></span></span><br> <span style=line-height:normal><b><span style=font-size:10.0pt><span cambria= style=font-family:><span style=color:#4f81bd>Conclusion:</span></span></span></b> <span style=font-size:10.0pt><span cambria= style=font-family:>Routine care combined with affective stimulation-based family-centered integrated spiritual support results in a better average pain and anxiety score.</span></span></span> Acute Coronary Syndrome,Anxiety,Chest Pain,Coronary Care Unit,Psychological Well-Being, 299 307 http://hehp.modares.ac.ir/browse.php?a_code=A-10-79668-1&slc_lang=en&sid=4