en Short Communication <div style=text-align: justify;><span style=font-size:12pt><span style=font-family:Calibri,sans-serif><b><span lang=EN-ID style=font-size:10.0pt><span cambria= style=font-family:><span style=color:#4472c4>Aims:</span></span></span></b><span lang=EN-ID style=font-size:10.0pt><span cambria= style=font-family:><span style=color:black> This study aimed to analyze the effect of knowledge on the application of clean and healthy living behavior through perceived susceptibility in the prevention of AIDS</span></span></span><span lang=EN-ID style=font-size:10.0pt><span cambria= style=font-family:><span style=color:black>.</span></span></span></span></span><br> <span style=font-size:12pt><span style=font-family:Calibri,sans-serif><b><span lang=EN-ID style=font-size:10.0pt><span cambria= style=font-family:><span style=color:#4472c4>Participants & Methods:</span></span></span></b> <span lang=EN-ID style=font-size:10.0pt><span cambria= style=font-family:><span style=color:black>Using</span></span></span><span lang=EN-ID style=font-size:10.0pt><span cambria= style=font-family:><span style=color:black> quantitative research, we examined the possible causality between certain factors possibly causing the studied symptoms. The statistical population was 290 people living in Wakatobi Regency, of whom 166 people were considered as samples using the Lemeshow formula. Descriptive and inferential analyses were performed using path analysis, t-test, and normality tests.</span></span></span></span></span><br> <span style=font-size:12pt><span style=font-family:Calibri,sans-serif><b><span lang=EN-ID style=font-size:10.0pt><span cambria= style=font-family:><span style=color:#4472c4>Findings:</span></span></span></b><span lang=EN-ID style=font-size:10.0pt><span cambria= style=font-family:><span style=color:black> Based on the results of the path analysis, the path coefficient value of the knowledge to perceived susceptibility was 0.177 with a t-value of 7.762 > 1.974 and a p-value of < 0.005. Thus, it can be concluded that knowledge has a positive and significant effect on clean and healthy living behavior in the community.</span></span></span></span></span><br> <span style=font-size:12pt><span style=font-family:Calibri,sans-serif><b><span lang=EN-ID style=font-size:10.0pt><span cambria= style=font-family:><span style=color:#4472c4>Conclusion:</span></span></span></b> <span lang=EN-ID style=font-size:10.0pt><span cambria= style=font-family:><span style=color:black>The</span></span></span><span lang=EN-ID style=font-size:10.0pt><span cambria= style=font-family:><span style=color:black> results showed that knowledge about the dangers of smoking had a significant effect on fostering clean and healthy behavior (PHBS) through perceived susceptibility.</span></span></span></span></span></div> Perception,Disease Susceptibility,Health,Behavior,Acquired Immunodeficiency Syndrome, 293 298 http://hehp.modares.ac.ir/browse.php?a_code=A-10-76169-2&slc_lang=en&sid=4 A. Asrina 1003194753284600297557 1003194753284600297557 Yes Department of Public Health, Faculty of Public Health, Universitas Muslim Indonesia, Makassar, Indonesia Y. Yusriani 1003194753284600297558 1003194753284600297558 No Department of Public Health, Faculty of Public Health, Universitas Muslim Indonesia, Makassar, Indonesia F.P. Idris 1003194753284600297559 1003194753284600297559 No Department of Public Health, Faculty of Public Health, Universitas Muslim Indonesia, Makassar, Indonesia M. Ikhtiar 1003194753284600297560 1003194753284600297560 No Department of Public Health, Faculty of Public Health, Universitas Muslim Indonesia, Makassar, Indonesia H. Amir 1003194753284600297561 1003194753284600297561 No Department of Nursing Science, Faculty of Public Health, Universitas Muslim Indonesia, Makassar, Indonesia