en <span style=font-size:10pt><span style=unicode-bidi:embed><span new= roman= style=font-family: times=><b><span cambria= style=font-family:>Aims:</span></b><span cambria= style=font-family:> The success of COVID-19 vaccination depends on public acceptance of the vaccine. It is necessary to evaluate the factors affecting vaccine acceptance to increase the acceptance of vaccination. The current study aimed to determine the relationships between the three components of the COM-B (capability, motivation, and opportunity) model and the explanatory domains of each component.</span><b> </b><span style=font-family:Cambria,serif></span></span></span></span><br> <span style=font-size:10pt><span style=unicode-bidi:embed><span new= roman= style=font-family: times=><b><span cambria= style=font-family:>Instrument </span></b><b><span cambria= style=font-family:>& Methods:</span></b><span cambria= style=font-family:> In this cross-sectional study, 1102 adults aged 18 years and older were selected through multi-stage sampling and received an online questionnaire on the WhatsApp platform in February 2021. Structure equation modeling was used to investigate the factors affecting vaccine acceptance.</span></span></span></span><br> <span style=font-size:10pt><span style=unicode-bidi:embed><span new= roman= style=font-family: times=><b><span cambria= style=font-family:>Findings</span></b><b><span cambria= style=font-family:>: </span></b><span cambria= style=font-family:>Of the 1102 respondents, 938 respondents (85.1%) wanted to get vaccinated. The main indicators for the COM-B components were behavioral regulation(capability), subjective norms and social support (opportunity) and social role (motivation). Opportunity strongly predicted motivation (93%) and Covid-19 vaccine acceptance (74%). Motivation and capability were mediator for opportunity on vaccine acceptance.</span></span></span></span><br> <span style=font-size:10pt><span style=unicode-bidi:embed><span new= roman= style=font-family: times=><b><span cambria= style=font-family:>Conclusion:</span></b><span cambria= style=font-family:> Providing environmental and interpersonal conditions by creating capability and motivation in people increases vaccine acceptance.</span></span></span></span><br> Opportunity,Motivation,Professional Competence,COVID-19 Virus Vaccines. 711 718 http://hehp.modares.ac.ir/browse.php?a_code=A-10-26709-1&slc_lang=en&sid=4