en <span style=font-size:10pt><span style=unicode-bidi:embed><span new= roman= style=font-family: times=><b><span cambria= style=font-family:>Aim</span></b><b><span cambria= style=font-family:>s:</span></b><span cambria= style=font-family:> COVID-19 has harmed people's lives and efforts are being made to speed up vaccinations. The growing problem of vaccine uncertainty may affect the uptake of the COVID-19 vaccine. The objectives of this study were to examine the determinants of COVID-19 vaccine acceptance.</span><b> </b></span></span></span><br> <span style=font-size:10pt><span style=unicode-bidi:embed><span new= roman= style=font-family: times=><b><span cambria= style=font-family:>Materials & Methods: </span></b><span cambria= style=font-family:>From</span><span cambria= style=font-family:> July 3 to September 25, 2021, we conducted a web-based, cross-sectional study among the citizens of Ardabil with a snowball sampling strategy under a highly restricted environment. A questionnaire was designed and filled out by 768 participants through social media and email. Associations between COVID-19 vaccine acceptance and determinants were explored using the chi-squared test. Key determinants that predict vaccine acceptance among respondents were modeled through logistic regression analysis.</span></span></span></span><br> <span style=font-size:10pt><span style=text-autospace:none><span style=unicode-bidi:embed><span new= roman= style=font-family: times=><b><span cambria= style=font-family:>Findings:</span></b><span cambria= style=font-family:> Of the 932 survey invitees, 768 responded to the questionnaire (response rate, 82.4%). The majority (55.2%) of the study participants were female. Of the 768 respondents, 486 (63.2%) showed interest to accept the COVID-19 vaccine. Willingness to get the vaccine is relatively high among older age groups (59.4% among 40+ year old), being married (56.9%), and city dwellers participants (83.09%). In multivariate model, respondents who were above 40 years (OR: 0.7; 95% CI:0.5-0.94), and married (OR: 1.43; 95% CI: 0.97-2.09) were significantly associated with vaccine acceptance (p<0.05). Besides, people having trust in the health system and vaccine were most likely to accept the vaccine (OR: 1.26; 95% CI: 1.01-1.56), and those having a higher perceived risk of acquiring infection were 4.83 times (OR: 4.83; 95% CI: 3.78-6.17) higher odds of accepting the vaccine.</span></span></span></span></span><br> <span style=font-size:10pt><span style=text-autospace:none><span style=unicode-bidi:embed><span new= roman= style=font-family: times=><b><span cambria= style=font-family:>Conclusion:</span></b><span cambria= style=font-family:> Our study identified religious/personal beliefs and risk perceptions as the most important predictors that would be affecting COVID-19 vaccine uptake. </span></span></span></span></span><br> COVID-19, vaccine, Cross-Sectional, Web-based 221 225 http://hehp.daneshafarand.org/browse.php?a_code=A-10-51722-5&slc_lang=en&sid=4 N. Nejaddadgar 1003194753284600287083 1003194753284600287083 No Department of Health Promotion and Education, School of Public Health, Ardabil University of Medical Sciences, Ardabil, Iran M. Jafarzadeh 1003194753284600287084 1003194753284600287084 No Department of Infectious Diseases, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran A. Ziapour 1003194753284600287085 1003194753284600287085 Yes Cardiovascular Research Center, Health Institute, Imam-Ali hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran F. Rezaei 1003194753284600287086 1003194753284600287086 No Health Education and Promotion Department, health deputy, Ministry of Health, Iran