en <span style=font-size:12pt><span style=font-family:Times New Roman,serif><strong><span style=font-size:10.0pt><span style=font-family:Cambria,serif><span style=color:#4f81bd>Aims:</span></span></span></strong> <span style=font-size:10.0pt><span style=font-family:Cambria,serif>Patient safety in anesthesia is critical due to the essential role of anesthesia in surgical and medical procedures. This study aimed to evaluate the effectiveness of a patient safety educational booklet on anesthesia technologists’ adherence to safety principles during the perioperative period.</span></span><span style=font-size:10.0pt><span style=font-family:Cambria,serif></span></span></span></span><br> <span style=font-size:12pt><span style=font-family:Times New Roman,serif><strong><span style=font-size:10.0pt><span style=font-family:Cambria,serif><span style=color:#4f81bd>Materials & Methods:</span></span></span></strong> <span style=font-size:10.0pt><span style=font-family:Cambria,serif>This quantitative semi-experimental study was conducted from 2023 to 2024 in two teaching hospitals affiliated with Iran University of Medical Sciences. Sixty-six anesthesia technologists were randomly assigned to intervention (n=33) and control (n=33) groups. The intervention group received a validated 60-page patient safety booklet developed through expert review and content validity analysis. Adherence to safety principles was assessed using a 31-item checklist covering the pre-, intra-, post-anesthesia, and recovery phases, with demonstrated reliability (ICC and Cronbach’s alpha=0.87). A blinded evaluator collected data before and after the intervention. Statistical analysis included McNemar tests, t-tests, and Fisher’s exact test (α=0.05).</span></span></span></span><br> <span style=font-size:12pt><span style=font-family:Times New Roman,serif><strong><span style=font-size:10.0pt><span style=font-family:Cambria,serif><span style=color:#4f81bd>Findings:</span></span></span></strong> <span style=font-size:10.0pt><span style=font-family:Cambria,serif>Following the intervention, the intervention group showed a significant improvement in adherence to patient safety principles compared to the control group. In the control group, some changes were noted, but their magnitude and consistency were significantly lower. Specifically, 19 out of 31 checklist items in the intervention group demonstrated significant positive changes (p<0.05) via McNemar’s test.</span></span></span></span><br> <span style=font-size:12pt><span style=font-family:Times New Roman,serif><strong><span style=font-size:10.0pt><span style=font-family:Cambria,serif><span style=color:#4f81bd>Conclusion:</span></span></span></strong><a name=_Hlk210636586> </a><span style=font-size:10.0pt><span style=font-family:Cambria,serif>Implementing validated educational booklets effectively enhances adherence to patient safety protocols among anesthesia technologists. </span></span></span></span><br> Anesthesia,Patient Safety,Health Education,Teaching Materials,Treatment Adherence and Compliance,Perioperative Care, 547 553 http://hehp.modares.ac.ir/browse.php?a_code=A-10-90076-1&slc_lang=en&sid=4