en Original Research <p data-end=571 data-start=280><span style=font-size:12pt><span style=line-height:normal><span style=font-family:Aptos,sans-serif><b><span style=font-size:10.0pt><span cambria= style=font-family:><span style=color:#4f81bd>Aims:</span></span></span></b> <span style=font-size:10.0pt><span cambria= style=font-family:>This systematic review aimed to investigate the attitudes, knowledge, skills, and usage of ChatGPT among educators and healthcare professionals worldwide, with a particular focus on its potential to enhance teaching and healthcare delivery across different socioeconomic contexts.</span></span></span></span></span><br> <span style=font-size:12pt><span style=line-height:normal><span style=font-family:Aptos,sans-serif><b><span style=font-size:10.0pt><span cambria= style=font-family:><span style=color:#4f81bd>Information & Methods:</span></span></span></b> <span style=font-size:10.0pt><span cambria= style=font-family:>A comprehensive literature search was conducted in PubMed, Embase, Scopus, and Web of Science, covering publications from October 30, 2022, to June 13, 2024. The selection process followed PRISMA guidelines, and the quality of the included studies was assessed using the Mixed Methods Appraisal Tool (MMAT). Studies examining ChatGPT’s influence on professionals’ attitudes, awareness, skills, or usage were considered. A total of 14 eligible studies were included in the final synthesis.</span></span></span></span></span><br> <span style=font-size:12pt><span style=line-height:normal><span style=font-family:Aptos,sans-serif><b><span style=font-size:10.0pt><span cambria= style=font-family:><span style=color:#4f81bd>Findings:</span></span></span></b> <span style=font-size:10.0pt><span cambria= style=font-family:>Among the 14 studies, 57% reported positive attitudes toward ChatGPT, recognizing its benefits in education and clinical settings. Additionally, 43% of the studies documented diverse use cases, such as educational content creation, student engagement, and clinical decision support. Awareness of ChatGPT varied significantly by region, with higher familiarity in high-income countries but greater enthusiasm observed in low- and middle-income countries. Skills assessment (36% of studies) identified strengths in language processing and content generation, but also limitations in managing complex, context-specific tasks.</span></span></span></span></span><br> <span style=font-size:12pt><span style=line-height:normal><span style=font-family:Aptos,sans-serif><b><span style=font-size:10.0pt><span cambria= style=font-family:><span style=color:#4f81bd>Conclusion:</span></span></span></b> <span style=font-size:10.0pt><span cambria= style=font-family:>ChatGPT holds significant promise for transforming education and healthcare, particularly in resource-constrained settings. </span></span></span></span></span><br> </p> ChatGPT,Artificial Intelligence,Education,Healthcare Professionals,Systematic Review,Attitudes,Knowledge, 579 586 http://hehp.modares.ac.ir/browse.php?a_code=A-10-83565-3&slc_lang=en&sid=4