en <span style=font-size:11pt><span style=line-height:normal><span style=font-family:Calibri,sans-serif><b><span style=font-size:10.0pt><span style=font-family:Cambria,serif><span style=color:#4f81bd>Aims:</span></span></span></b> <span lang=IN style=font-size:10.0pt><span style=font-family:Cambria,serif>This study evaluated the effectiveness of information digitization using the ENNOE method in enhancing knowledge and treatment adherence among people living with AIDS. </span></span><span style=font-size:10.0pt><span style=font-family:Cambria,serif></span></span></span></span></span><br> <span style=font-size:11pt><span style=line-height:normal><span style=font-family:Calibri,sans-serif><b><span style=font-size:10.0pt><span style=font-family:Cambria,serif><span style=color:#4f81bd>Materials & Methods:</span></span></span></b> <span lang=IN style=font-size:10.0pt><span style=font-family:Cambria,serif>This study employed a research and development design, followed by a one-group pre-test-post-test approach with 30 randomly selected participants undergoing antiretroviral therapy, </span></span><span style=font-size:10.0pt><span style=font-family:Cambria,serif>and </span></span><span lang=IN style=font-size:10.0pt><span style=font-family:Cambria,serif>was conducted in 2024 in Jambi City, Indonesia. The intervention was delivered through the ENNOE method, which encompasses engagement, education, monitoring, and adherence. Data were collected using structured questionnaires assessing knowledge and antiretroviral therapy adherence before and after the intervention. Statistical analyses, including chi-square tests, paired t-tests, and Cohen’s d effect size, were conducted to evaluate the intervention’s effectiveness.</span></span><span style=font-size:10.0pt><span style=font-family:Cambria,serif></span></span></span></span></span><br> <span style=font-size:11pt><span style=line-height:normal><span style=font-family:Calibri,sans-serif><b><span style=font-size:10.0pt><span style=font-family:Cambria,serif><span style=color:#4f81bd>Findings:</span></span></span></b><span style=font-size:10.0pt><span style=font-family:Cambria,serif> The baseline patient knowledge and adherence to antiretroviral therapy were relatively low prior to the intervention. However, a significant improvement was observed following the intervention. The mean knowledge score increased from 43.0±4.7 to 60.8±6.9 (p=0.001, Cohen’s d=3.01), while medication adherence improved from 57.7±2.5 to 68.5±5.1 (p=0.001, Cohen’s d=2.68), demonstrating a substantial effect. Additionally, education level and marital status were identified as factors influencing antiretroviral therapy adherence.</span></span><span style=font-size:10.0pt><span style=font-family:Cambria,serif></span></span></span></span></span><br> <span style=font-size:11pt><span style=line-height:normal><span style=font-family:Calibri,sans-serif><b><span style=font-size:10.0pt><span style=font-family:Cambria,serif><span style=color:#4f81bd>Conclusion:</span></span></span></b><span style=font-size:10.0pt><span style=font-family:Cambria,serif> The ENNOE method through digital health information delivery enhance</span></span><span style=font-size:10.0pt><span style=font-family:Cambria,serif>s</span></span><span lang=IN style=font-size:10.0pt><span style=font-family:Cambria,serif> knowledge and adherence to antiretroviral therapy among people living with HIV. </span></span></span></span></span><br> Health Literacy,Medication Adherence,HIV Infections,Patient Education as Topic, 205 211 http://hehp.modares.ac.ir/browse.php?a_code=A-10-87510-1&slc_lang=en&sid=4 N. Nuriyah 1003194753284600359861 1003194753284600359861 Yes Department of Medical, Faculty of Mathematic and Science Programe, Jambi University, Jambi, Indonesia M. Rusdi 1003194753284600359862 1003194753284600359862 No Department of Chemistry Education, Faculty of Teacher Training and Education, Jambi University, Jambi, Indonesia S. Elfrida 1003194753284600359863 1003194753284600359863 No Department of Public Health Sciences, Health Polytechnic Ministry of Health Jambi, Jambi, Indonesia M.H. Effendi 1003194753284600359864 1003194753284600359864 No Department of Chemistry Education, Faculty of Teacher Training and Education, Jambi University, Jambi, Indonesia