en <span style=font-size:11pt><span style=line-height:normal><span style=font-family:Calibri,sans-serif><b><span style=font-size:10.0pt><span style=font-family:Cambria,serif><span style=color:#4f81bd>Aims:</span></span></span></b><span style=font-size:10.0pt><span style=font-family:Cambria,serif> Heart transplantation significantly alters the lifestyle and quality of life of children and adolescents post-surgery. These patients must strictly adhere to their treatment regimens to maintain graft viability and achieve better adaptation. Enhancing the quality of life in pediatric heart transplant recipients is a critical responsibility of nurses. This study aimed to evaluate the impact of a tele-nursing supportive educational program on treatment adherence and quality of life in children aged 12-18 years.</span></span></span></span></span><br> <span style=font-size:11pt><span style=line-height:normal><span style=font-family:Calibri,sans-serif><b><span lang=EN-GB style=font-size:10.0pt><span style=font-family:Cambria,serif><span style=color:#4f81bd>Materials & Methods:</span></span></span></b> <span style=font-size:10.0pt><span style=font-family:Cambria,serif>This quasi-experimental study with a single-group design without a control group was done on 41 pediatric patients who were referred to a specialized hospital for heart transplantation in Tehran in 2022. Participants were selected through census sampling and received education via communication platforms, such as WhatsApp, Skype, and Telegram, as chosen by the patients and their parents. The program spanned eight weeks, during which data were collected using a socio-demographic questionnaire, the Pediatric Quality of Life Inventory for Cardiac Problems, and the Modanloo Medication Adherence Scale. Pre- and post-test results were analyzed using SPSS version 16.</span></span></span></span></span><br> <span style=font-size:11pt><span style=line-height:normal><span style=font-family:Calibri,sans-serif><b><span lang=EN-GB style=font-size:10.0pt><span style=font-family:Cambria,serif><span style=color:#4f81bd>Findings:</span></span></span></b> <span style=font-size:10.0pt><span style=font-family:Cambria,serif>There was a significant improvement in the mean quality of life score and its dimensions (p=0.001), as well as the medication adherence score and its dimensions (p=0.001) after the implementation and follow-up of the intervention program.</span></span></span></span></span><br> <span style=font-size:11pt><span style=line-height:normal><span style=font-family:Calibri,sans-serif><b><span style=font-size:10.0pt><span style=font-family:Cambria,serif><span style=color:#4f81bd>Conclusion:</span></span></span></b><span style=font-size:10.0pt><span style=font-family:Cambria,serif> Tele-nursing interventions offer an effective and accessible approach to enhancing treatment adherence and improving the quality of life for pediatric heart transplant recipients.</span></span></span></span></span> Treatment Adherence,Heart Transplantation,Children,Telenursing,Quality of Life, 675 682 http://hehp.modares.ac.ir/browse.php?a_code=A-10-85507-1&slc_lang=en&sid=4 S.M. Hosseini Moghadam 1003194753284600349369 1003194753284600349369 No “Student Research Committee” and “Department of Pediatric Nursing, School of Nursing and Midwifery”, Shahid Beheshti University of Medical Sciences, Tehran, Iran M. Babaie 1003194753284600349370 1003194753284600349370 No Department of Anesthesiology, School of Allied Medical Sciences, Alborz University of Medical Sciences, Karaj, Iran M. Nourian 1003194753284600349371 1003194753284600349371 No Department of Pediatric Nursing, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran M. Mahdavi 1003194753284600349372 1003194753284600349372 No Heart Research Center, Shaheed Rajaie Cardiovascular Medical and Research Center, Tehran, Iran M. Nasiri 1003194753284600349373 1003194753284600349373 No Department of Biostatistics, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran M. Varzeshnejad 1003194753284600349374 1003194753284600349374 Yes Department of Pediatric Nursing, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran