en <div style=text-align: justify;><strong>Aims: </strong>Drugs can change the conscious state for pleasure by altering users' perceptions, feelings, and emotions. This study aimed to assess the effectiveness of Interactive Learning Multimedia compared to lecture methods in increasing the knowledge of the dangers of drug abuse.<br> <strong>Instrument & Methods:</strong> This quasi-experimental research was conducted in 2020 on grade IV elementary school students. Fifty-six students were selected by random cluster sampling method and randomly divided into multimedia learning groups (experimental) and lecture groups (control). Data was collected by the Knowledge on the Dangers of Drug Abuse questionnaire. Data were entered into the SPSS 18 software, and the covariance statistical test was used to determine the effectiveness of interactive learning multimedia<br> <strong>Findings:</strong> The pretest scores of lecture and multimedia groups were 84.5±12.3 and 82.9±11.9, respectively. The posttest scores of lecture and multimedia groups were 89.1±12.0 and 98.6±10.5, respectively (p<0.05).<br> <strong>Conclusion: </strong>Using interactive multimedia learning can increase the knowledge of the dangers of drug abuse in school children better than lecture learning. <br> </div> Drug Abuse,Elementary Students,Interactive Multimedia Learning,Narcotics, 481 485 http://hehp.modares.ac.ir/browse.php?a_code=A-10-64949-1&slc_lang=en&sid=4 W. Achmad Basari Eko achmadbasari@student.uns.ac.id 1003194753284600236601 1003194753284600236601 Yes Faculty of Teacher Training and Education, Sebelas Maret University, Kota Surakarta, Indonesia