en <div style=text-align: justify;><strong>Aims:</strong> <a name=_Hlk8913089>Psychological well-being is a key concept in preventing health problems and increasing life expectancy. Psychological well-being is associated with some positive psychological structures. The purpose of this study was to investigate the mediating role of resilience and self-efficacy in the relationship between cognitive emotion regulation and the psychological well-being of Iranian students.</a><br> <strong>Materials & Methods:</strong> In this cross-sectional descriptive study, 285 students (142 men and 143 women) were selected by multistage sampling method from Zanjan University, Zanjan, Iran in the academic year of 2017-2018. Data were collected using psychological well-being, resilience, self-efficacy, and cognitive-emotional regulation questionnaires. Data were analyzed by LISREL 8.8 and SPSS-20 software using Pearson correlation coefficient and structural equation modeling (SEM).<br> <strong>Findings:</strong> Psychological well-being had a direct relation with resilience, self-efficacy, and catastrophizing strategy. Cognitive emotion regulation strategies showed a direct relationship with resilience and self-efficacy and finally, resilience, and self-efficacy in the relationship between cognitive emotional regulation and psychological well-being strategies had a complete mediating role and incomplete mediating role, respectively.<br> <strong>Conclusion:</strong> Resilience and self-efficacy play a mediating role in the relationship between psychological well-being and cognitive emotion regulation strategies in Iranian students.</div> Cognitive Emotion Regulation, Resilience, Self-Efficacy, Psychological Well-Being, Students 183 190 http://hehp.modares.ac.ir/browse.php?a_code=A-10-50424-1&slc_lang=en&sid=4 S. Roohi 1003194753284600161608 1003194753284600161608 No General Psychology Department, Psychology & Educational Sciences Faculty, Zanjan University, Zanjan, Iran H. Noroozi 1003194753284600161609 1003194753284600161609 No Clinical Psychology Department, Psychology & Educational Sciences Faculty, Semnan University, Semnan, Iran M. Yousefi Afrashteh mjdyosefi@gmail.com 1003194753284600161610 1003194753284600161610 Yes General Psychology Department, Psychology & Educational Sciences Faculty, University of Zanjan, Zanjan, Iran